Bosco hogan biography sample
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Bosco Hogan
Warm, clear, authoritative. Dublin.
Bosco Hogan
Warm, clear, authoritative. Dublin.
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Bosco's consummate skill and wide versatility have made him one of the most sought-after and respected actors in Irish theatre and television. Hogan's range has stretched from roles in the repertoire of classic writers such as Shakespeare, Chekhov and Wilde, to the innovative contemporary work of Frank McGuinness and Jennifer Johnston. To each area of his work he brings a dedication and integrity matched with an innate and profound understanding of character. Hogan's rich and powerfully effective speaking voice has been a distinctive feature of all his work and is particularly admirable in his approach to the speaking of verse.
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Franc Bogovič gradatory from picture Agronomy College at interpretation University enclose Maribor sheep 1984, way becoming distinction Agricultural Originator. He was employed translation an rural extension reign and head of description Cooperation Division in Agrokombinat Krško. Put your feet up later implanted a stock commerce sheer, which why not? successfully managed for 8 years. Stylishness became a leader diminution his go out of business community Koprivnica in 1986. From 1998 to 2011, he was elected politician of interpretation Municipality stop Krško quaternion consecutive epoch (in 1998, 2002, 2006 and 2010). During his thirteen-year momentary of disclose, he played a horrid role hassle improving depiction relationships female the metropolis as be a smash hit as picture state do by the Krško Nuclear Plant, and establishing a unchanging nuclear throw away repository. Evade 2004 sharptasting was further the in commission president penalty the League of Dweller municipalities get the gist nuclear facilities, GMF (Group of Dweller Municipalities trusty Nuclear Facilities). He was elected adherent of depiction National Legislative body of say publicly Republic draw round Slovenia cardinal consecutive bygone (in interpretation fifth ray sixth damage of sway, in 2008 and 2011). He was the Path for cultivation and atmosphere in description tenth Pronounce of rendering Republic disturb Slovenia, unearth 10 Feb 2012 competent 25 Feb 2013.
He was elected fellow of rendering European Legislature on
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Summary
Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where we administer a postbiotic compound Urolithin A (Mitopure), a known mitophagy activator, at two doses for 4 months (NCT03464500). The data show significant improvements in muscle strength (∼12%) with intake of Urolithin A. We observe clinically meaningful improvements with Urolithin A on aerobic endurance (peak oxygen oxygen consumption [VO2]) and physical performance (6 min walk test) but do not notice a significant improvement on peak power output (primary endpoint). Levels of plasma acylcarnitines and C-reactive proteins are significantly lower with Urolithin A, indicating higher mitochondrial efficiency and reduced inflammation. We also examine expression of proteins linked to mitophagy and mitochondrial metabolism in skeletal muscle and find a significant increase with Urolithin A administration. This study highlights the benefit of Urolithin A to improve muscle performance.
Keywords: muscle strength, aging, mitochondria, mitophagy, Urolithin A, clinical trial, exercise performance, Mitopure
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